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1

Finding New Hits in Neglected Disease Projects: Target or Phenotypic Based Screening?

H. Gilbert, Ian, Leroy, Didier, A. Frearson, Julie

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 149 KB

english, 2011

2

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

Ruth Brenk, Alessandro Schipani, Daniel James, Agata Krasowski, Ian Hugh Gilbert, Julie Frearson, Paul Graham Wyatt

Journal:

Year:

2008

Language:

english

File:

PDF, 603 KB

english, 2008

3

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

Stephen Patterson, Deuan C. Jones, Emma J. Shanks, Julie A. Frearson, Ian H. Gilbert, Paul G. Wyatt, Alan H. Fairlamb

Journal:

Year:

2009

Language:

english

File:

PDF, 403 KB

english, 2009

4

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

Daniel Spinks, Emma J. Shanks, Laura A. T. Cleghorn, Stuart McElroy, Deuan Jones, Daniel James, Alan H. Fairlamb, Julie A. Frearson, Paul G. Wyatt, Ian H. Gilbert

Journal:

Year:

2009

Language:

english

File:

PDF, 366 KB

english, 2009

5

Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009)

John L. Richardson, Isabelle R. E. Nett, Deuan C. Jones, Mohamed H. Abdille, Ian H. Gilbert, Alan H. Fairlamb, Stephen Patterson, Deuan C. Jones, Emma J. Shanks, Julie A. Frearson, Paul G. Wyatt

Journal:

Year:

2009

Language:

english

File:

PDF, 1.00 MB

english, 2009

6

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Daniel Spinks, Dr. Leah S. Torrie, Dr. Stephen Thompson, Dr. Justin R. Harrison, Prof. Julie A. Frearson, Dr. Kevin D. Read, Prof. Alan H. Fairlamb, Prof. Paul G. Wyatt, Prof. Ian H. Gilbert

Journal:

Year:

2012

Language:

english

File:

PDF, 318 KB

english, 2012

7

Acetazolamide-based fungal chitinase inhibitors

Alexander W. Schüttelkopf, Ludovic Gros, David E. Blair, Julie A. Frearson, Daan M.F. van Aalten, Ian H. Gilbert

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.09 MB

english, 2010

8

Quinol derivatives as potential trypanocidal agents

Amy Capes, Stephen Patterson, Susan Wyllie, Irene Hallyburton, Iain T. Collie, Andrew J. McCarroll, Malcolm F.G. Stevens, Julie A. Frearson, Paul G. Wyatt, Alan H. Fairlamb, Ian H. Gilbert

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 482 KB

english, 2012

9

Target assessment for antiparasitic drug discovery

Julie A. Frearson, Paul G. Wyatt, Ian H. Gilbert, Alan H. Fairlamb

Journal:

Trends in Parasitology

Year:

2007

Language:

english

File:

PDF, 979 KB

english, 2007

10

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.74 MB

english, 2011

11

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti- Trypanosoma brucei Drug Discovery Lead Molecules

Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A. T., Ojo, Kayode K., Van Voorhis, Wesley C., Brenk, Ruth, Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.57 MB

english, 2013

12

Reviews

Burns, A. L., Millar, T. B., Webb, J. B., Frearson, K. S., Wilson, Ian, Low, D. A., Ray, S. N., Martin, Jean I.

Journal:

Australian Outlook

Year:

1964

Language:

english

File:

PDF, 1.15 MB

english, 1964

13

Back Cover: From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti- Trypanosoma brucei Drug Discovery Lead Molecules (ChemMedChem 7/2013)

Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A. T., Ojo, Kayode K., Van Voorhis, Wesley C., Brenk, Ruth, Frearson, Julie A., Gilbert, Ian H., Wyatt, Paul G.

Journal:

Year:

2013

File:

PDF, 876 KB

2013

14

The effects of environmental temperature on the properties of myofibrillar adenosine triphosphatase from various species of fish

Johnston, Ian A., Frearson, Neil, Goldspink, Geoffrey

Journal:

Biochemical Journal

Year:

1973

Language:

english

File:

PDF, 532 KB

english, 1973

15

Geometric evolution and ice dynamics during a surge of Bakaninbreen, Svalbard

Murray, Tavi, Dowdeswell, Julian A., Drewry, David J., Frearson, Ian

Journal:

Journal of Glaciology

Year:

1998

Language:

english

File:

PDF, 8.97 MB

english, 1998